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Best Gaming Mouse for Big Hands – 2021 Buying Guide

Hey, when it comes to buying a gaming mouse for big hands, it’s important you figure out the right size for you.

Keeping that in mind I made this list for you so you can find the right mouse for you. There are all kinds of mouse in this list like small and light, big and heavy to find what is right for you.

Here is the list of the best gaming mouse for big hands:

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Microsoft Natural Wireless Laser Mouse 6000

The main draw to the 6000 is its unconventional yet comfortable shape, as well as a few interesting features.


Anyone who’s had the displeasure of dealing with a computer-related repetitive stress injury will tell you that even the simplest of tasks (like moving a mouse around) can become excruciatingly painful. And while there are plenty of ergonomic mice on the market, they’re often expensive, oddly shaped, or both.

Microsoft’s take on the ergonomic mouse strikes a delicate balance between usability and relief. It’s a bit taller than an average mouse, and its sloped design forces your hand into a more natural “handshake” position which works wonders to relieve inflammation of the tendons running along the underside of your wrist.

There are also two programmable buttons located between the thumb and index finger, but they’re so hard to effectively manipulate that most users will likely forgo using them altogether. They’re just out of thumb’s reach and placed too far back to be clicked by the index finger quickly enough to make the effort worthwhile.

  • Great natural hand placement
  • Quick learning curve
  • Long battery life
  • Wireless range is a bit limited
  • Awkward side button and scroll wheel placement
  • Uses standard AA batteries instead of rechargeable ones
Best Gaming Mouse for Big Hands - 2021 Buying Guide 1

Logitech G502 Proteus Spectrum

The Logitech G502 Proteus Spectrum is good for FPS gaming. It has low click latency, it feels well-built, and it has a comfortable right-handed shape that’s well-suited for larger hands using any grip type.


The Logitech G502 Proteus Spectrum is a very good wired gaming mouse. It feels very well-made, has plenty of programmable buttons, low click latency, and a comfortable right-handed shape with a thumb rest. That said, it’s quite large, and while it’s well-suited to all grip types, it’s only suitable for larger hands.

It also includes a set of five 3.6g weights if you’d like to adjust the center of gravity or add more weight, though it’s already a heavy mouse.

Unfortunately, the CPI range isn’t as wide as those found on later versions, and our unit’s sensor is inconsistent and undershoots the set CPI more during quick cursor movements than slow ones. There’s also an updated version of this mouse called the Logitech G502 HERO.

  • Feels very well-built.

  • Low click latency.
  • Lots of programmable inputs and companion software with plenty of customization options.
  • Software is compatible with Windows and macOS.

  • Fairly heavy.

  • The braided cable isn’t as flexible as most paracord-like cables.
  • Mouse feet are only decent and glide roughly on tables.
Best Gaming Mouse for Big Hands - 2021 Buying Guide 2

Logitech G903 LIGHTSPEED

This is a great gaming mouse for playing FPS games. It has an excellent low lag and offers a responsive gaming experience. It’s highly customizable, offers excellent performance.


The Logitech G903 LIGHTSPEED is a great gaming mouse. It has the excellent build quality and great ergonomics. It’s suitable for use with either hand and you can use any grip you prefer. People with small hands, however, might find some buttons not as comfortable to reach when using the fingertip grip.

This mouse has excellent overall performance with low click latency and high precision and allows for many adjustments. It’s equipped with a large number of customizable buttons that you can program with the accompanying software, which is very versatile and has no compatibility issues.

  • Great mouse for gaming.
  • Very well-built design.
  • Excellent performance; customizable.
  • Excellent, versatile vertical wheel.
  • Lacks receiver dongle storage for easier portability.
  • No Bluetooth connectivity.
Best Gaming Mouse for Big Hands - 2021 Buying Guide 3

Logitech G602

The Logitech G602 is a very good gaming mouse for playing MMO games. Its shape is comfortable for long hours of gaming and it has a lot of side buttons for instant access to your spells and abilities.


The Logitech G602 is a good overall wireless mouse. It connects to its USB receiver to get a very low click latency and has great sensor performance. Fans of high sensitivity might be a bit disappointed by its maximum 2500 CPI, but most people should be fine.

Its body and shape are very comfortable for a palm grip, especially due to its thumb rest. It has a lot of programmable buttons and it can be customized on both Windows and macOS, which is great.

  • Good build quality.
  • Good performance customization.
  • Comfortable design; best suited for palm grip.
  • Bulky and heavy design.
  • Doesn’t have a high maximum CPI.
Best Gaming Mouse for Big Hands - 2021 Buying Guide 4

Corsair Nightsword RGB

Very good for MMOs. It offers ten programmable buttons, which isn’t as many as dedicated MMO mice. 


The Corsair Nightsword is a comfortable gaming mouse with RGB lighting and an ergonomic design thanks to its slanted shape with a thumb rest. It offers a few programmable buttons, although it isn’t on par with a dedicated MMO mouse in that regard.

Also, its sensor is quite inconsistent, as it overshoots when moving the mouse fast and undershoots when moving it slowly. The mouse also isn’t recommended for people with small hands, as it’s a bit big. On the upside, it’s very well-built and has great customization options.

  • Very low click latency.
  • Very well-built design.
  • Great for palm and claw grips.
  • Inconsistent sensor.
  • Stiff cable.


We have hope you find the right gaming mouse for you. Top performance mouse for gambling or any other activity if you have large hands are all mentioned above to help you.

There a lot of articles on gaming peripherals like mouse, mousepad, headset, and much more Go Check Out our website. Which I’m sure will help you.


Written by Ritvik

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